STM32U5 achieves 19 μA/MHz in Run mode and 300 nA in Standby, setting a benchmark for ultra-low-power microcontrollers in battery-operated IoT nodes. TrustZone and PSA Certified Level 3 security provide hardware root-of-trust, secure boot, and encrypted OTA firmware updates, meeting IEC 62443-4-2 IoT device security requirements. 2 MB dual-bank flash allows live firmware updates without service interruption. The 3D hardware accelerator for SHA/AES/PKA cryptography offloads security processing from the application core, maintaining throughput with minimal power overhead. The Arduino and ST Morpho headers support over 500 expansion boards from the STM32 ecosystem.